Steerable laser probe

ABSTRACT

A steerable laser probe may include a handle having a handle proximal end and a handle distal end, an actuation structure of the handle, a housing sleeve, a shape memory sleeve at least partially disposed within the housing sleeve, and an optic fiber disposed within the shape memory sleeve and within an inner bore of the handle. A compression of the actuation structure may be configured to gradually curve the optic fiber. A compression of the actuation structure may be configured to gradually straighten the optic fiber. A decompression of the actuation structure may be configured to gradually curve the optic fiber. A decompression of the actuation structure may be configured to gradually straighten the optic fiber.

CROSS-REFERENCE TO RELATED APPLICATIONS

This Application claims the benefit of U.S. Provisional Application No.61/530852, filed Sep. 2, 2011.

FIELD OF THE INVENTION

The present disclosure relates to a surgical instrument, and, moreparticularly, to a steerable laser probe.

BACKGROUND OF THE INVENTION

A wide variety of ophthalmic procedures require a laser energy source.For example, ophthalmic surgeons may use laser photocoagulation to treatproliferative retinopathy. Proliferative retinopathy is a conditioncharacterized by the development of abnormal blood vessels in the retinathat grow into the vitreous humor. Ophthalmic surgeons may treat thiscondition by energizing a laser to cauterize portions of the retina toprevent the abnormal blood vessels from growing and hemorrhaging.

In order to increase the chances of a successful laser photocoagulationprocedure, it is important that a surgeon is able aim the laser at aplurality of targets within the eye, e.g., by guiding or moving thelaser from a first target to a second target within the eye. It is alsoimportant that the surgeon is able to easily control a movement of thelaser. For example, the surgeon must be able to easily direct a laserbeam by steering the beam to a first position aimed at a first target,guide the laser beam from the first position to a second position aimedat a second target, and hold the laser beam in the second position.Accordingly, there is a need for a surgical laser probe that can beeasily guided to a plurality of targets within the eye.

BRIEF SUMMARY OF THE INVENTION

The present disclosure provides a steerable laser probe. In one or moreembodiments, a steerable laser probe may comprise a handle having ahandle proximal end and a handle distal end, an actuation structure ofthe handle, a housing sleeve, a shape memory sleeve at least partiallydisposed within the housing sleeve, and an optic fiber disposed withinthe shape memory sleeve and within an inner bore of the handle.Illustratively, a compression of the actuation structure may beconfigured to gradually curve the optic fiber. In one or moreembodiments, a compression of the actuation structure may be configuredto gradually straighten the optic fiber. Illustratively, a decompressionof the actuation structure may be configured to gradually curve theoptic fiber. In one or more embodiments, a decompression of theactuation structure may be configured to gradually straighten the opticfiber.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and further advantages of the present invention may be betterunderstood by referring to the following description in conjunction withthe accompanying drawings in which like reference numerals indicateidentical or functionally similar elements:

FIGS. 1A and 1B are schematic diagrams illustrating a handle;

FIG. 2 illustrates an exploded view of a steerable laser probe assembly;

FIGS. 3A, 3B, and 3C illustrate a gradual curving of an optic fiber;

FIGS. 4A, 4B, and 4C illustrate a gradual straightening of an opticfiber;

FIGS. 5A and 5B are schematic diagrams illustrating a handle;

FIG. 6 illustrates an exploded view of a steerable laser probe assembly;

FIGS. 7A, 7B, and 7C illustrate a gradual curving of an optic fiber;

FIGS. 8A, 8B, and 8C illustrate a gradual straightening of an opticfiber;

FIGS. 9A and 9B are schematic diagrams illustrating a handle;

FIGS. 10A and 10B are schematic diagrams illustrating an actuationnosecone;

FIG. 11 illustrates an exploded view of a steerable laser probeassembly;

FIGS. 12A, 12B, and 12C illustrate a gradual curving of an optic fiber;

FIGS. 13A, 13B, and 13C illustrate a gradual straightening of an opticfiber;

FIGS. 14A and 14B are schematic diagrams illustrating a handle;

FIG. 15 illustrates an exploded view of a steerable laser probeassembly;

FIGS. 16A, 16B, and 16C illustrate a gradual curving of an optic fiber;

FIGS. 17A, 17B, and 17C illustrate a gradual straightening of an opticfiber;

FIGS. 18A and 18B are schematic diagrams illustrating a handle;

FIG. 19 illustrates an exploded view of a steerable laser probeassembly;

FIGS. 20A, 20B, and 20C illustrate a gradual curving of an optic fiber;

FIGS. 21A, 21B, and 21C illustrate a gradual straightening of an opticfiber.

DETAILED DESCRIPTION OF AN ILLUSTRATIVE EMBODIMENT

FIGS. 1A and 1B are schematic diagrams illustrating a handle 100. FIG.1A illustrates a top view of handle 100. In one or more embodiments,handle 100 may comprise a handle distal end 101, a handle proximal end102, an actuation structure 110, and a handle base 120. Illustratively,actuation structure 110 comprises an actuation structure distal end 111and an actuation structure proximal end 112. In one or more embodiments,actuation structure 110 may comprise a plurality of actuation arms 113.Illustratively, each actuation arm 113 may comprise at least oneextension mechanism 114. In one or more embodiments, actuation structure110 may comprise a shape memory material configured to project actuationstructure distal end 111 a first distance from actuation structureproximal end 112 when actuation structure 110 is fully decompressed.Actuation structure 110 may comprise a shape memory material configuredto project actuation structure distal end 111 a second distance fromactuation structure proximal end 112 when actuation structure 110 isfully compressed. Illustratively, the second distance may be greaterthan the first distance. Actuation structure 110 may be manufacturedfrom any suitable material, e.g., polymers, metals, metal alloys, etc.,or from any combination of suitable materials.

Illustratively, actuation structure 110 may be compressed by anapplication of a compressive force to actuation structure 110. In one ormore embodiments, actuation structure 110 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 110.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure110. For example, a surgeon may compress actuation structure 110 bysqueezing actuation structure 110. Illustratively, the surgeon maycompress actuation structure 110 by squeezing actuation structure 110 atany particular location of a plurality of locations around an outerperimeter of actuation structure 110. For example, a surgeon may rotatehandle 100 and compress actuation structure 110 from any rotationalposition of a plurality of rotational positions of handle 100.

In one or more embodiments, actuation structure 110 may be compressed byan application of a compressive force to any one or more of theplurality of actuation arms 113. Illustratively, each actuation arm 113may be configured to actuate independently. In one or more embodiments,each actuation arm 113 may be connected to one or more of the pluralityof actuation arms 113 wherein an actuation of a particular actuation arm113 may be configured to actuate every actuation arm 113 of theplurality of actuation arms 113. In one or more embodiments, acompression of actuation structure 110, e.g., due to an application of acompressive force to a particular actuation arm 113, may be configuredto actuate the particular actuation arm 113. Illustratively, anactuation of the particular actuation arm 113 may be configured toactuate every actuation arm 113 of the plurality of actuation arms 113.In one or more embodiments, an application of a compressive force to aparticular actuation arm 113 may be configured to extend at least oneextension mechanism 114 of the particular actuation arm 113.Illustratively, a particular actuation arm 113 may extend a first lengthfrom handle base 120. An extension of an extension mechanism 114 of theparticular actuation arm 113, e.g., due to an application of acompressive force to the particular actuation arm 113, may be configuredto extend the particular actuation arm a second length from handle base120. Illustratively, the second length from handle base 120 may begreater than the first length from handle base 120.

FIG. 1B illustrates a cross-sectional view of handle 100. In one or moreembodiments, handle 100 may comprise an inner bore 130, a distal bore140, an inner bore proximal taper 150, a fixation mechanism chamber 160,and a shape memory sleeve guide 165. Illustratively, handle 100 maycomprise a fixation lip 115 connected to actuation structure distal end111. Handle 100 may be manufactured from any suitable material, e.g.,polymers, metals, metal alloys, etc., or from any combination ofsuitable materials.

FIG. 2 illustrates an exploded view of a steerable laser probe assembly200. In one or more embodiments, steerable laser probe assembly 200 maycomprise a handle 100, a proximal fixation mechanism 210, a distalfixation mechanism 220, an outer nosecone 230 having an outer noseconedistal end 231 and an outer nosecone proximal end 232, an inner nosecone240 having an inner nosecone distal end 241 and an inner noseconeproximal end 242, a housing sleeve 250 having a housing sleeve distalend 251 and a housing sleeve proximal end 252, a shape memory sleeve 260having a shape memory sleeve distal end 261 and a shape memory sleeveproximal end 262, an optic fiber 270 having an optic fiber distal end271 and an optic fiber proximal end 272, and a light source interface280. Illustratively, light source interface 280 may be configured tointerface with optic fiber proximal end 272. In one or more embodiments,light source interface 280 may comprise a standard light sourceconnecter, e.g., an SMA connector.

Illustratively, outer nosecone proximal end 232 may be fixed actuationstructure 110, e.g., outer nosecone 230 may be fixed to fixation lip115. In one or more embodiments, housing tube proximal end 252 may befixed to inner nosecone distal end 241. Illustratively, distal fixationmechanism 220 may be configured to attach outer nosecone 230 and innernosecone 240, e.g., outer nosecone distal end 231 may be fixed to innernosecone proximal end 242. For example, distal fixation mechanism 220may comprise a set screw configured to firmly attach outer nosecone 230to inner nosecone 240. In one or more embodiments, distal fixationmechanism 220 may comprise an adhesive material configured to attachouter nosecone 230 to inner nosecone 240, or distal fixation mechanism220 may comprise one or more magnets configured to attach outer nosecone230 to inner nosecone.

Illustratively, optic fiber 270 may be disposed within shape memorysleeve 260, e.g., optic fiber distal end 271 may be adjacent to shapememory sleeve distal end 261. Optic fiber 270 may be fixed in a positionwithin shape memory sleeve 260, e.g., with a biocompatible adhesive orany suitable fixation means. In one or more embodiments, shape memorysleeve 260 may comprise a pre-bent angle 265 configured to curve opticfiber 270 towards pre-bent angle 265. Illustratively, shape memorysleeve 260 may comprise a shape memory material, e.g., Nitinol,configured to curve optic fiber 270 towards one or more surgical targetswithin an eye. Shape memory sleeve 260 may be manufactured from anysuitable material, e.g., polymers, metals, metal alloys, etc., or fromany combination of suitable materials.

Illustratively, optic fiber 270 and shape memory sleeve 260 may bedisposed within inner bore 130, shape memory sleeve guide 165, fixationmechanism chamber 160, distal bore 140, outer nosecone 230, innernosecone 240, and housing sleeve 250. In one or more embodiments, opticfiber 270 and shape memory sleeve 260 may be fixed in a positionrelative to handle 100, e.g., by proximal fixation mechanism 210,wherein a compression of actuation structure 110 may actuate housingsleeve 250 relative to optic fiber 270 and shape memory sleeve 260.Illustratively, proximal fixation mechanism 210 may be configured to fixoptic fiber 270 and shape memory sleeve 260, e.g., at fixation mechanismchamber 160, in a position relative to handle 100, e.g., such that whenactuation structure 110 is fully decompressed, optic fiber distal end271 extends from housing sleeve distal end 251 and shape memory sleeve260 curves optic fiber 270 at pre-bent angle 265. In one or moreembodiments, proximal fixation mechanism 210 may be configured to fixoptic fiber 270 and shape memory sleeve 260, e.g., at fixation mechanismchamber 160, in a position relative to handle 100, e.g., such that whenactuation structure 110 is fully compressed, optic fiber distal end 271is contained within housing sleeve 250, e.g., optic fiber distal end 271does not extend from housing sleeve distal end 251, and shape memorysleeve 260 and optic fiber 270 are temporarily straightened by housingsleeve 250.

FIGS. 3A, 3B, and 3C illustrate a gradual curving of an optic fiber 270.FIG. 3A illustrates a straightened optic fiber 300. Illustratively,straightened optic fiber 300 may be fully contained within housingsleeve 250. In one or more embodiments, optic fiber 270 and shape memorysleeve 260 may be fully contained within housing sleeve 250, e.g., whenactuation structure 110 is fully compressed. Illustratively, when opticfiber 270 and shape memory sleeve 260 are fully contained within housingsleeve 250, pre-bent angle 265 of shape memory sleeve 260 may bestraightened by housing sleeve 250. For example, an angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271 maybe 180 degrees, e.g., when housing sleeve 250 contains a straightenedoptic fiber 300.

FIG. 3B illustrates a partially curved optic fiber 310. In one or moreembodiments, a decompression of actuation structure 110 may beconfigured to gradually retract housing sleeve 250 to expose optic fiber270 and shape memory sleeve 260. Illustratively, as optic fiber 270 andshape memory sleeve 260 are gradually exposed by a retraction of housingsleeve 250, shape memory sleeve 260 may cause optic fiber 270 to curvetowards pre-bent angle 265. In one or more embodiments, a decompressionof actuation structure 110 may cause a straightened optic fiber 300 togradually curve to a partially curved optic fiber 310. Illustratively, adecompression of actuation structure 110 may gradually expose opticfiber 270 and shape memory sleeve 260 causing optic fiber 270 togradually curve towards pre-bent angle 265. For example, as an exposedlength of optic fiber 270 and shape memory sleeve 260 is increased,e.g., by a retraction of housing sleeve 250, an angle between housingsleeve 250 and a line tangent to optic fiber distal end 271 may bedecreased. Illustratively, optic fiber 270 and shape memory sleeve 260may be exposed from housing sleeve distal end 251 at a first length witha first angle between housing sleeve 250 and a line tangent to opticfiber distal end 271. A retraction of housing sleeve 250, e.g., due to adecompression of actuation structure 110, may expose optic fiber 270 andshape memory sleeve 260 from housing sleeve distal end 251 at a secondlength with a second angle between housing sleeve 250 and a line tangentto optic fiber distal end 271. Illustratively, the second length may begreater than the first length and the second angle may be less than thefirst angle.

FIG. 3C illustrates a fully curved optic fiber 320. Illustratively, whenhousing sleeve 250 is fully retracted, e.g., by a full decompression ofactuation structure 110, housing sleeve 250 may expose a fully curvedoptic fiber 320. In one or more embodiments, a decompression ofactuation structure 110 may cause a partially curved optic fiber 310 togradually curve to a fully curved optic fiber 320. Illustratively, whenhousing sleeve 250 is retracted to expose a partially curved optic fiber310, optic fiber 270 and shape memory sleeve 260 may be exposed fromhousing sleeve distal end 251 at a partially extended length with apartially extended angle between housing sleeve 250 and a line tangentto optic fiber distal end 271. A retraction of housing sleeve 250, e.g.,due to a full decompression of actuation structure 110, may expose opticfiber 270 and shape memory sleeve 260 from housing sleeve distal end 251at fully extended length with a fully extended angle between housingsleeve 250 and a line tangent to optic fiber distal end 271, e.g., whenhousing sleeve 250 is retracted to expose a fully curved optic fiber320. Illustratively, the fully extended length may be greater than thepartially extended length and the fully extended angle may be less thanthe partially extended angle.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing sleeve 250 extendsfrom inner nosecone distal end 241 may be adjusted to vary an amount ofdecompression of actuation structure 110 configured to expose aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a position of fixationmechanism chamber 160 and proximal fixation mechanism 210 or a length ofoptic fiber 270 and shape memory sleeve 260 extending distally from aposition of proximal fixation mechanism 210 may be adjusted to vary anamount of decompression of actuation structure 110 configured to exposea particular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. For example, a distance that innernosecone 240 extends from outer nosecone distal end 231 may be adjustedto vary an amount of decompression of actuation structure 110 configuredto expose a particular length of optic fiber 270 and shape memory sleeve260 from housing sleeve distal end 251. In one or more embodiments, ageometry of actuation structure 110 may be adjusted to vary an amount ofdecompression of actuation structure 110 configured to expose aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a magnitude of pre-bentangle 265 may be adjusted to vary a magnitude of an angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271 whena particular length of optic fiber 270 and shape memory sleeve 260 isexposed from housing sleeve distal end 251.

FIGS. 4A, 4B, and 4C illustrate a gradual straightening of an opticfiber 270. FIG. 4A illustrates a refracted housing sleeve 400.Illustratively, a retracted housing sleeve 400 may expose at least aportion of optic fiber 270 and shape memory sleeve 260 from housingsleeve distal end 251. In one or more embodiments, a full decompressionof actuation structure 110 may be configured to cause housing sleeve 250to be retracted relative to optic fiber 270 and shape memory sleeve 260such that a fully curved optic fiber 320 is exposed from housing sleevedistal end 251. Illustratively, housing sleeve 250 may comprise arefracted housing sleeve 400, e.g., due to a full decompression ofactuation structure 110.

FIG. 4B illustrates a partially extended housing sleeve 410.Illustratively, a partially extended housing sleeve 410 may hold aportion of pre-bent angle 265 in a straightened position within housingsleeve 250. In one or more embodiments, a compression of actuationstructure 110 may extend housing sleeve 250 over optic fiber 270 andshape memory sleeve 260 causing shape memory sleeve 260 to graduallystraighten optic fiber 270 from a fully curved optic fiber 320 to apartially curved optic fiber 310.

FIG. 4C illustrates a fully extended housing sleeve 420. Illustratively,a fully extended housing sleeve 420 may hold pre-bent angle 265 in astraightened position within housing sleeve 250. In one or moreembodiments, a full compression of actuation structure 110 may extendhousing sleeve 250 over optic fiber 270 and shape memory sleeve 260causing shape memory sleeve 260 to gradually straighten optic fiber 270from a partially curved optic fiber 310 to a straightened optic fiber300.

Illustratively, a surgeon may aim optic fiber distal end 271 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 100 to orient shape memory sleeve260 in an orientation configured to cause a curvature of optic fiber 270within the particular transverse plane of the inner eye and varying anamount of compression of actuation structure 110. Illustratively, asurgeon may aim optic fiber distal end 271 at any target within aparticular sagittal plane of the inner eye by, e.g., rotating handle 100to orient shape memory sleeve 260 in an orientation configured to causea curvature of optic fiber 270 within the particular sagittal plane ofthe inner eye and varying an amount of compression of actuationstructure 110. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular frontal plane of theinner eye by, e.g., varying an amount of compression of actuationstructure 110 to orient a line tangent to optic fiber distal end 271wherein the line tangent to optic fiber distal end 271 is within theparticular frontal plane of the inner eye and rotating handle 100.Illustratively, a surgeon may aim optic fiber distal end 271 at anytarget located outside of the particular transverse plane, theparticular sagittal plane, and the particular frontal plane of the innereye, e.g., by varying a rotational orientation of handle 100 and varyingan amount of compression of actuation structure 110.

FIGS. 5A and 5B are schematic diagrams illustrating a handle 500. FIG.5A illustrates a top view of handle 500. In one or more embodiments,handle 500 may comprise a handle distal end 501, a handle proximal end502, an actuation structure 510, and a handle base 520. Illustratively,actuation structure 510 may comprise a plurality of actuation arms 513.In one or more embodiments, each actuation arm 513 may comprise at leastone extension mechanism 514.

Illustratively, actuation structure 510 may be compressed by anapplication of a compressive force to actuation structure 510. In one ormore embodiments, actuation structure 510 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 510.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure510. For example, a surgeon may compress actuation structure 510 bysqueezing actuation structure 510. Illustratively, the surgeon maycompress actuation structure 510 by squeezing actuation structure 510 atany particular location of a plurality of locations around an outerperimeter of actuation structure 510. For example, a surgeon may rotatehandle 500 and compress actuation structure 510 from any rotationalposition of a plurality of rotational positions of handle 500.

In one or more embodiments, actuation structure 510 may be compressed byan application of a compressive force to any one or more of theplurality of actuation arms 513. Illustratively, each actuation arm 513may be configured to actuate independently. In one or more embodiments,each actuation arm 513 may be connected to one or more of the pluralityof actuation arms 513 wherein an actuation of a particular actuation arm513 may be configured to actuate every actuation arm 513 of theplurality of actuation arms 513. In one or more embodiments, acompression of actuation structure 510, e.g., due to an application of acompressive force to a particular actuation arm 513, may be configuredto actuate the particular actuation arm 513. Illustratively, anactuation of the particular actuation arm 513 may be configured toactuate every actuation arm 513 of the plurality of actuation arms 513.In one or more embodiments, an application of a compressive force to aparticular actuation arm 513 may be configured to extend at least oneextension mechanism 514 of the particular actuation arm 513, e.g.,relative to housing sleeve 250. Illustratively, a compression of aparticular actuation arm 513 may be configured to extend at least oneextension mechanism 514 relative to housing sleeve 250 by retractinghousing sleeve 250 relative to handle 500.

FIG. 5B illustrates a cross-sectional view of handle 500. In one or moreembodiments, handle 500 may comprise an inner bore 530, an inner boredistal cone 540, an inner bore proximal taper 550, an optic fiber guide560, a shape memory sleeve guide 565, a fixation mechanism chamber 570,and a pressure mechanism housing 580. Handle 500 may be manufacturedfrom any suitable material, e.g., polymers, metals, metal alloys, etc.,or from any combination of suitable materials.

FIG. 6 illustrates an exploded view of a steerable laser probe assembly600. In one or more embodiments, steerable laser probe assembly 600 maycomprise a handle 500, a fixation mechanism 610, a pressure mechanism630 having a pressure mechanism distal end 631 and a pressure mechanismproximal end 632, an actuation cone 640 having an actuation cone distalend 641 and an actuation cone proximal end 642, a housing sleeve 250having a housing sleeve distal end 251 and a housing sleeve proximal end252, a shape memory sleeve 260 having a shape memory sleeve distal end261 and a shape memory sleeve proximal end 262, an optic fiber 270having an optic fiber distal end 271 and an optic fiber proximal end272, and a light source interface 280. Illustratively, housing sleeveproximal end 252 may be fixed to actuation cone distal end 641.

In one or more embodiments, pressure mechanism 630 may be disposed inpressure mechanism housing 580. Illustratively, actuation cone 640 maybe at least partially disposed within actuation structure 510, e.g.,wherein pressure mechanism distal end 631 abuts actuation cone proximalend 642. For example, actuation cone proximal end 642 may always bedisposed within actuation structure 510. In one or more embodiments, acompression of actuation structure 510 may cause actuation cone 640 tobe partially retracted into actuation structure 510. Illustratively, adecompression of actuation structure 510 may cause actuation cone 640 tobe partially extended from actuation structure 510.

In one or more embodiments, pressure mechanism 630 may be configured toprovide a force. Illustratively, pressure mechanism 630 may beconfigured to provide a force to resist a retraction of actuation cone640 into actuation structure 510. For example, pressure mechanism 630may be configured to provide a force to facilitate an extension ofactuation cone 640 from actuation structure 510. In one or moreembodiments, pressure mechanism 630 may comprise a spring.Illustratively, a compression of actuation structure 510 may cause acompression of pressure mechanism 630 and a decompression of actuationstructure 510 may cause a decompression of pressure mechanism 630.Pressure mechanism 630 may be manufactured from any suitable material,e.g., polymers, metals, metal alloys, etc., or from any combination ofsuitable materials.

Illustratively, as actuation cone 640 is gradually retracted intoactuation structure 510, e.g., due to a compression of actuationstructure 510, housing sleeve 250 is also gradually retracted relativeto handle 500. In one or more embodiments, as actuation cone 640 isgradually extended from actuation structure 510, e.g., due to adecompression of actuation structure 510, housing sleeve 250 is alsogradually extended relative to handle 500. Illustratively, optic fiber270 may be disposed within shape memory sleeve 260, e.g., such thatoptic fiber distal end 271 is adjacent to shape memory sleeve distal end261. Optic fiber 270 may be fixed in a position within shape memorysleeve 260, e.g., with a biocompatible adhesive or any suitable fixationmeans. In one or more embodiments, optic fiber 270 may be disposedwithin inner bore 530 and optic fiber guide 560. Illustratively, opticfiber 270 and shape memory sleeve 260 may be disposed within shapememory sleeve guide 565, pressure mechanism housing 580, actuation cone640, and housing sleeve 250. In one or more embodiments, optic fiber 270and shape memory sleeve 260 may be disposed within pressure mechanism630. Illustratively, optic fiber 270 and shape memory sleeve 260 may beheld fixed relative to handle 500, e.g., by fixation mechanism 610, atfixation mechanism housing 570.

In one or more embodiments, a compression of actuation structure 510 maybe configured to gradually expose optic fiber 270 and shape memorysleeve 260 from housing sleeve distal end 251. Illustratively, asactuation structure 510 is compressed, actuation cone 640 may begradually retracted into actuation structure 510 and housing sleeve 250may be gradually retracted relative optic fiber 270 and shape memorysleeve 260 to gradually expose optic fiber 270 and shape memory sleeve260 from housing sleeve distal end 251. In one or more embodiments, asoptic fiber 270 and shape memory sleeve 260 are gradually exposed byhousing sleeve 250, shape memory sleeve 260 may gradually curve opticfiber 270 towards pre-bent angle 265.

In one or more embodiments, a decompression of actuation structure 510may be configured to gradually extend housing sleeve 250 over opticfiber 270 and shape memory sleeve 260. Illustratively, as actuationstructure 510 is decompressed, a portion of actuation cone 640 may begradually extended from actuation structure 510 and housing sleeve 250may be gradually extended relative to optic fiber 270 and shape memorysleeve 260. In one or more embodiments, as housing sleeve 250 isgradually extended over optic fiber 270 and shape memory sleeve 260,optic fiber 270 and shape memory sleeve 260 may be graduallystraightened, e.g., as housing sleeve 250 gradually straightens pre-bentangle 265.

FIGS. 7A, 7B, and 7C illustrate a gradual curving of an optic fiber 270.FIG. 7A illustrates a straightened optic fiber 700. Illustratively,straightened optic fiber 700 is fully contained within housing sleeve250. In one or more embodiments, optic fiber 270 and shape memory sleeve260 may be fully contained within housing sleeve 250, e.g., whenactuation structure 510 is fully decompressed. For example, whenactuation structure 510 is fully decompressed, pressure mechanism 630may extend actuation cone 640 from actuation structure 510.Illustratively, when optic fiber 270 and shape memory sleeve 260 arefully contained within housing sleeve 250, pre-bent angle 265 of shapememory sleeve 260 may be straightened by housing sleeve 250. Forexample, an angle between housing sleeve 250 and a line tangent to opticfiber distal end 271 may be, e.g., 180 degrees, when housing sleeve 250contains a straightened optic fiber 700.

FIG. 7B illustrates a partially curved optic fiber 710. In one or moreembodiments, a compression of a fully decompressed actuation structure510 may be configured to gradually retract housing sleeve 250 relativeto optic fiber 270 and shape memory sleeve 260 causing optic fiber 270and shape memory sleeve 260 to be gradually exposed from housing sleevedistal end 251. For example, as actuation structure 510 is compressed,actuation cone 640 may be partially retracted into actuation structure510. In one or more embodiments, pressure mechanism 630 may beconfigured to provide a resistive force to resist a retraction ofactuation cone 640 into actuation structure 510. Illustratively, asoptic fiber 270 and shape memory sleeve 260 are gradually exposed by aretraction of housing sleeve 250, shape memory sleeve 260 may causeoptic fiber 270 to curve towards pre-bent angle 265. In one or moreembodiments, a compression of actuation structure 510 may cause astraightened optic fiber 700 to gradually curve to a partially curvedoptic fiber 710.

Illustratively, a compression of actuation structure 510 may graduallyexpose optic fiber 270 and shape memory sleeve 260 from housing sleevedistal end 251 as housing sleeve 250 is gradually retracted. As housingsleeve 250 is gradually retracted shape memory sleeve 260 may causeoptic fiber 270 to gradually curve towards pre-bent angle 265. Forexample, as an exposed length of optic fiber 270 and shape memory sleeve260 is increased, e.g., by a retraction of housing sleeve 250, an anglebetween housing sleeve 250 and a line tangent to optic fiber distal end271 may be decreased.

Illustratively, optic fiber 270 and shape memory sleeve 260 may beexposed from housing sleeve 250 at a first length with a first anglebetween housing sleeve 250 and a line tangent to optic fiber distal end271. A retraction of housing sleeve 250, e.g., due to a compression ofactuation structure 510, may expose optic fiber 270 and shape memorysleeve 260 from housing sleeve 250 at a second length with a secondangle between housing sleeve 250 and a line tangent to optic fiberdistal end 271. Illustratively, the second length may be greater thanthe first length and the second angle may be less than the first angle.

FIG. 7C illustrates a fully curved optic fiber 720. Illustratively, whenhousing sleeve 250 is fully retracted, e.g., by a full compression ofactuation structure 510, housing sleeve 250 may expose a fully curvedoptic fiber 720. For example, as actuation structure 510 is fullycompressed, actuation cone 640 may be fully retracted into actuationstructure 510. In one or more embodiments, pressure mechanism 630 may beconfigured to provide a resistive force to resist a retraction ofactuation cone 640 into actuation structure 510. In one or moreembodiments, a compression of actuation structure 510 may cause apartially curved optic fiber 710 to gradually curve to a fully curvedoptic fiber 720. Illustratively, when housing sleeve 250 is retracted toexpose a partially curved optic fiber 710, optic fiber 270 and shapememory sleeve 260 may be exposed from housing sleeve 250 at a partiallyextended length with a partially extended angle between housing sleeve250 and a line tangent to optic fiber distal end 271. A retraction ofhousing sleeve 250, e.g., due to a full compression of actuationstructure 510, may expose optic fiber 270 and shape memory sleeve 260from housing sleeve 250 at fully extended length with a fully extendedangle between housing sleeve 250 and a line tangent to optic fiberdistal end 271, e.g., when housing sleeve 250 is retracted to expose afully curved optic fiber 720. Illustratively, the fully extended lengthmay be greater than the partially extended length and the fully extendedangle may be less than the partially extended angle.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing sleeve 250 extendsfrom actuation cone distal end 641 may be adjusted to vary an amount ofcompression of actuation structure 510 configured to expose a particularlength of optic fiber 270 and shape memory sleeve 260 from housingsleeve distal end 251. Illustratively, a position of fixation mechanismchamber 570 and fixation mechanism 610 or a length of optic fiber 270and shape memory sleeve 260 extending distally from a position offixation mechanism 610 may be adjusted to vary an amount of compressionof actuation structure 510 configured to expose a particular length ofoptic fiber 270 and shape memory sleeve 260 from housing sleeve distalend 251. In one or more embodiments, a geometry of actuation structure510 or a geometry of actuation cone 640 may be adjusted to vary anamount of compression of actuation structure 510 configured to expose aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. For example, one or more properties ofpressure mechanism 630 may be adjusted to vary an amount of forceconfigured to compress actuation structure 510. Illustratively, amagnitude of pre-bent angle 265 may be adjusted to vary a magnitude ofan angle between housing sleeve 250 and a line tangent to optic fiberdistal end 271 when a particular length of optic fiber 270 and shapememory sleeve 260 is exposed from housing sleeve distal end 251.

FIGS. 8A, 8B, and 8C illustrate a gradual straightening of an opticfiber 270. FIG. 8A illustrates a retracted housing sleeve 800.Illustratively, a retracted housing sleeve 800 may expose at least aportion of optic fiber 270 and shape memory sleeve 260 from housingsleeve distal end 251. In one or more embodiments, a full compression ofactuation structure 510 may cause housing sleeve 250 to actuate relativeto optic fiber 270 and shape memory sleeve 260 such that a fully curvedoptic fiber 720 is exposed from housing sleeve distal end 251.Illustratively, housing sleeve 250 may comprise a retracted housingsleeve 800, e.g., due to a full compression of actuation structure 510.For example, as actuation structure 510 is fully compressed, actuationcone 640 may be fully retracted into actuation structure 510.

FIG. 8B illustrates a partially extended housing sleeve 810.Illustratively, a partially extended housing sleeve 810 may hold aportion of pre-bent angle 265 in a straightened position within housingsleeve 250. In one or more embodiments, a decompression of actuationstructure 510 may extend housing sleeve 250 over optic fiber 270 andshape memory sleeve 260 causing shape memory sleeve 260 to graduallystraighten optic fiber 270 from a fully curved optic fiber 720 to apartially curved optic fiber 710. For example, as actuation structure510 is decompressed, actuation cone 640 may be partially extended fromactuation structure 510. In one or more embodiments, pressure mechanism630 may be configured to provide a facilitating force to facilitate anextension of actuation cone 640 from actuation structure 510.

FIG. 8C illustrates a fully extended housing sleeve 820. Illustratively,a fully extended housing sleeve 820 may hold pre-bent angle 265 in astraightened position within housing sleeve 250. In one or moreembodiments, a full decompression of actuation structure 510 may extendhousing sleeve 250 over optic fiber 270 and shape memory sleeve 260causing shape memory sleeve 260 to gradually straighten optic fiber 270from a partially curved optic fiber 710 to a straightened optic fiber700. For example, as actuation structure 510 is fully decompressed,actuation cone 640 may be fully extended from actuation structure 510.In one or more embodiments, pressure mechanism 630 may be configured toprovide a facilitating force to facilitate an extension of actuationcone 640 from actuation structure 510.

Illustratively, a surgeon may aim optic fiber distal end 271 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 500 to orient shape memory sleeve260 in an orientation configured to cause a curvature of optic fiber 270within the particular transverse plane of the inner eye and varying anamount of compression of actuation structure 510. Illustratively, asurgeon may aim optic fiber distal end 271 at any target within aparticular sagittal plane of the inner eye by, e.g., rotating handle 500to orient shape memory sleeve 260 in an orientation configured to causea curvature of optic fiber 270 within the particular sagittal plane ofthe inner eye and varying an amount of compression of actuationstructure 510. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular frontal plane of theinner eye by, e.g., varying an amount of compression of actuationstructure 510 to orient a line tangent to optic fiber distal end 271wherein the line tangent to optic fiber distal end 271 is within theparticular frontal plane of the inner eye and rotating handle 500.Illustratively, a surgeon may aim optic fiber distal end 271 at anytarget located outside of the particular transverse plane, theparticular sagittal plane, and the particular frontal plane of the innereye, e.g., by varying a rotational orientation of handle 500 and varyingan amount of compression of actuation structure 510.

FIGS. 9A and 9B are schematic diagrams illustrating a handle 900. FIG.9A illustrates a top view of handle 900. In one or more embodiments,handle 900 may comprise a handle distal end 901, a handle proximal end902, an actuation structure 910, and a handle base 920. Illustratively,actuation structure 910 may comprise a plurality of actuation arms 913.In one or more embodiments, each actuation arm 913 may comprise at leastone extension mechanism 914.

Illustratively, actuation structure 910 may be compressed by anapplication of a compressive force to actuation structure 910. In one ormore embodiments, actuation structure 910 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 910.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure910. For example, a surgeon may compress actuation structure 910 bysqueezing actuation structure 910. Illustratively, the surgeon maycompress actuation structure 910 by squeezing actuation structure 910 atany particular location of a plurality of locations around an outerperimeter of actuation structure 910. For example, a surgeon may rotatehandle 900 and compress actuation structure 910 from any rotationalposition of a plurality of rotational positions of handle 900.

In one or more embodiments, actuation structure 910 may be compressed byan application of a compressive force to any one or more of theplurality of actuation arms 913. Illustratively, each actuation arm 913may be configured to actuate independently. In one or more embodiments,each actuation arm 913 may be connected to one or more of the pluralityof actuation arms 913 wherein an actuation of a particular actuation arm913 may be configured to actuate every actuation arm 913 of theplurality of actuation arms 913. In one or more embodiments, acompression of actuation structure 910, e.g., due to an application of acompressive force to a particular actuation arm 913, may be configuredto actuate the particular actuation arm 913. Illustratively, anactuation of the particular actuation arm 913 may be configured toactuate every actuation arm 913 of the plurality of actuation arms 913.In one or more embodiments, an application of a compressive force to aparticular actuation arm 913 may be configured to extend at least oneextension mechanism 914 of the particular actuation arm 913.Illustratively, a particular actuation arm 913 may extend a first lengthfrom handle base 920. An extension of an extension mechanism 914 of theparticular actuation arm 913, e.g., due to an application of acompressive force to the particular actuation arm 913, may be configuredto extend the particular actuation arm a second length from handle base920. Illustratively, the second length from handle base 920 may begreater than the first length from handle base 920.

FIG. 9B illustrates a cross-sectional view of handle 900. In one or moreembodiments, handle 900 may comprise an inner bore 930, an inner boredistal cone 940, an inner bore proximal taper 950, an optic fiber guide960, a shape memory sleeve guide 965, a fixation mechanism chamber 970,and a piston tube proximal housing 980. Handle 900 may be manufacturedfrom any suitable material, e.g., polymers, metals, metal alloys, etc.,or from any combination of suitable materials.

FIGS. 10A and 10B are schematic diagrams illustrating an actuationnosecone 1000. FIG. 10A is a schematic diagram illustrating a top viewof actuation nosecone 1000. Illustratively, actuation nosecone 1000comprises an actuation nosecone distal end 1001 and an actuationnosecone proximal end 1002. FIG. 10B is a schematic diagram illustratinga cross-sectional view of actuation nosecone 1000. In one or moreembodiments, actuation nosecone 1000 may comprise an actuation structureinterface 1010, a piston tube distal housing 1020, and a shape memorysleeve distal guide 1030.

FIG. 11 illustrates an exploded view of a steerable laser probe assembly1100. In one or more embodiments, steerable laser probe assembly 1100may comprise a handle 900, a fixation mechanism 1110, a piston tube 1130having a piston tube distal end 1131 and a piston tube proximal end1132, an actuation nosecone 1000, a housing sleeve 250 having a housingsleeve distal end 251 and a housing sleeve proximal end 252, a shapememory sleeve 260 having a shape memory sleeve distal end 261 and ashape memory sleeve proximal end 262, an optic fiber 270 having an opticfiber distal end 271 and an optic fiber proximal end 272, and a lightsource interface 280. Illustratively, housing sleeve proximal end 252may be fixed to actuation nosecone distal end 1001.

In one or more embodiments, piston tube 1130 may be disposed betweenpiston tube distal housing 1020 and piston tube proximal housing 980.Illustratively, piston tube distal end 1131 may be fixed to actuationnosecone proximal end 1002. In one or more embodiments, handle distalend 901 may be configured to interface with actuation structureinterface 1010 wherein a compression of actuation structure 910 mayextend actuation nosecone 1000 relative to handle 900. Illustratively,handle distal end 901 may be configured to interface with actuationstructure interface 1010 wherein a decompression of actuation structure910 may retract actuation nosecone 1000 relative to handle 900.

Illustratively, optic fiber 270 may be disposed within shape memorysleeve 260, e.g., such that optic fiber distal end 271 is adjacent toshape memory sleeve distal end 261. Optic fiber 270 may be fixed in aposition within shape memory sleeve 260, e.g., with a biocompatibleadhesive or any suitable fixation means. In one or more embodiments,optic fiber 270 may be disposed within inner bore 930 and optic fiberguide 960.

Illustratively, optic fiber 270 and shape memory sleeve 260 may bedisposed within shape memory sleeve guide 965, piston tube proximalhousing 980, piston tube 1130, piston tube distal housing 1020, shapememory sleeve distal guide 1030, and housing sleeve 250. Illustratively,optic fiber 270 and shape memory sleeve 260 may be held fixed relativeto handle 900, e.g., by fixation mechanism 1110, at fixation mechanismhousing 970.

In one or more embodiments, a decompression of actuation structure 910may be configured to cause housing sleeve 250 to be refracted relativeto optic fiber 270 and shape memory sleeve 260. Illustratively, adecompression of actuation structure 910 may be configured to retractactuation nosecone 1000 and housing sleeve 250 relative to handle 900.In one or more embodiments, a decompression of actuation structure 910may be configured to cause housing sleeve 250 to be gradually retractedrelative to optic fiber 270 and shape memory sleeve 260 wherein opticfiber 270 and shape memory sleeve 260 may be gradually exposed fromhousing sleeve distal end 251. In one or more embodiments, as opticfiber 270 and shape memory sleeve 260 are gradually exposed by housingsleeve 250, shape memory sleeve 260 may gradually curve optic fiber 270towards pre-bent angle 265.

In one or more embodiments, a compression of actuation structure 910 maybe configured to cause housing sleeve 250 to be extended relative tooptic fiber 270 and shape memory sleeve 260. Illustratively, acompression of actuation structure 910 may be configured to extendactuation nosecone 1000 and housing sleeve 250 relative to handle 900.In one or more embodiments, a compression of actuation structure 910 maybe configured to cause housing sleeve 250 to be gradually extendedrelative to optic fiber 270 and shape memory sleeve 260 wherein opticfiber 270 and shape memory sleeve 260 may be gradually covered byhousing sleeve 250. In one or more embodiments, as housing sleeve 250 isgradually extended over optic fiber 270 and shape memory sleeve 260,optic fiber 270 and shape memory sleeve 260 may be graduallystraightened, e.g., as housing sleeve 250 gradually straightens pre-bentangle 265.

FIGS. 12A, 12B, and 12C illustrate a gradual curving of an optic fiber270. FIG. 12A illustrates a straightened optic fiber 1200.Illustratively, straightened optic fiber 1200 is fully contained withinhousing sleeve 250. In one or more embodiments, optic fiber 270 andshape memory sleeve 260 may be fully contained within housing sleeve250, e.g., when actuation structure 910 is fully compressed. Forexample, when actuation structure 910 is fully compressed, actuationnosecone 1000 may be fully extended relative to handle 900.Illustratively, when optic fiber 270 and shape memory sleeve 260 arefully contained within housing sleeve 250, pre-bent angle 265 of shapememory sleeve 260 may be straightened by housing sleeve 250. Forexample, an angle between housing sleeve 250 and a line tangent to opticfiber distal end 271 may be, e.g., 180 degrees, when housing sleeve 250contains a straightened optic fiber 1200.

FIG. 12B illustrates a partially curved optic fiber 1210. In one or moreembodiments, a decompression of a fully compressed actuation structure910 may gradually retract housing sleeve 250 to expose optic fiber 270and shape memory sleeve 260. For example, as actuation structure 910 isdecompressed, actuation nosecone 1000 may be refracted relative tohandle 900. Illustratively, as optic fiber 270 and shape memory sleeve260 are gradually exposed by a refraction of housing sleeve 250, shapememory sleeve 260 may cause optic fiber 270 to curve towards pre-bentangle 265. In one or more embodiments, a decompression of actuationstructure 910 may cause a straightened optic fiber 1200 to graduallycurve to a partially curved optic fiber 1210. Illustratively, adecompression of actuation structure 910 may gradually expose opticfiber 270 and shape memory sleeve 260 causing optic fiber 270 togradually curve towards pre-bent angle 265. For example, as an exposedlength of optic fiber 270 and shape memory sleeve 260 is increased,e.g., by a retraction of housing sleeve 250, an angle between housingsleeve 250 and a line tangent to optic fiber distal end 271 may bedecreased. Illustratively, optic fiber 270 and shape memory sleeve 260may be exposed from housing sleeve distal end 251 at a first length witha first angle between housing sleeve 250 and a line tangent to opticfiber distal end 271. A retraction of housing sleeve 250, e.g., due to adecompression of actuation structure 910, may expose optic fiber 270 andshape memory sleeve 260 from housing sleeve distal end 251 at a secondlength with a second angle between housing sleeve 250 and a line tangentto optic fiber distal end 271. Illustratively, the second length may begreater than the first length and the second angle may be less than thefirst angle.

FIG. 12C illustrates a fully curved optic fiber 1220. Illustratively,when housing sleeve 250 is fully retracted, e.g., by a fulldecompression of actuation structure 910, housing sleeve 250 may exposea fully curved optic fiber 1220. For example, when actuation structure910 is fully decompressed, actuation nosecone 1000 may be fullyretracted relative to handle 900. In one or more embodiments, adecompression of actuation structure 910 may cause a partially curvedoptic fiber 1210 to gradually curve to a fully curved optic fiber 1220.Illustratively, when housing sleeve 250 is retracted to expose apartially curved optic fiber 1210, optic fiber 270 and shape memorysleeve 260 may be exposed from housing sleeve distal end 251 at apartially extended length with a partially extended angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271. Aretraction of housing sleeve 250, e.g., due to a full decompression ofactuation structure 910, may expose optic fiber 270 and shape memorysleeve 260 from housing sleeve distal end 251 at fully extended lengthwith a fully extended angle between housing sleeve 250 and a linetangent to optic fiber distal end 271, e.g., when housing sleeve 250 isretracted to expose a fully curved optic fiber 1220. Illustratively, thefully extended length may be greater than the partially extended lengthand the fully extended angle may be less than the partially extendedangle.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing sleeve 250 extendsfrom actuation nosecone distal end 1001 may be adjusted to vary anamount of decompression of actuation structure 910 configured to exposea particular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a position of fixationmechanism chamber 970 and fixation mechanism 1110 or a length of opticfiber 270 and shape memory sleeve 260 extending distally from a positionof fixation mechanism 1110 may be adjusted to vary an amount ofdecompression of actuation structure 910 configured to expose aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. In one or more embodiments, a geometry ofactuation structure 910 or a geometry of actuation nosecone 1000 may beadjusted to vary an amount of decompression of actuation structure 910configured to expose a particular length of optic fiber 270 and shapememory sleeve 260 from housing sleeve distal end 251. Illustratively, amagnitude of pre-bent angle 265 may be adjusted to vary a magnitude ofan angle between housing sleeve 250 and a line tangent to optic fiberdistal end 271 when a particular length of optic fiber 270 and shapememory sleeve 260 is exposed from housing sleeve distal end 251.

FIGS. 13A, 13B, and 13C illustrate a gradual straightening of an opticfiber 270. FIG. 13A illustrates a retracted housing sleeve 1300.Illustratively, a refracted housing sleeve 1300 may expose at least aportion of optic fiber 270 and shape memory sleeve 260 from housingsleeve distal end 251. In one or more embodiments, a full decompressionof actuation structure 910 may be configured to cause housing sleeve 250to be retracted relative to optic fiber 270 and shape memory sleeve 260such that a fully curved optic fiber 1220 is exposed from housing sleevedistal end 251. Illustratively, housing sleeve 250 may comprise aretracted housing sleeve 1300, e.g., due to a full decompression ofactuation structure 910. For example, when actuation structure 910 isfully decompressed, actuation nosecone 1000 may be fully refractedrelative to handle 900.

FIG. 13B illustrates a partially extended housing sleeve 1310.Illustratively, a partially extended housing sleeve 1310 may hold aportion of pre-bent angle 265 in a straightened position within housingsleeve 250. In one or more embodiments, a compression of actuationstructure 910 may extend housing sleeve 250 over optic fiber 270 andshape memory sleeve 260 causing shape memory sleeve 260 to graduallystraighten optic fiber 270 from a fully curved optic fiber 1220 to apartially curved optic fiber 1210. For example, a compression of a fullydecompressed actuation structure 910 may partially extend actuationnosecone 1000 relative to handle 900.

FIG. 13C illustrates a fully extended housing sleeve 1320.Illustratively, a fully extended housing sleeve 1320 may hold pre-bentangle 265 in a straightened position within housing sleeve 250. In oneor more embodiments, a full compression of actuation structure 910 mayextend housing sleeve 250 over optic fiber 270 and shape memory sleeve260 causing shape memory sleeve 260 to gradually straighten optic fiber270 from a partially curved optic fiber 1210 to a straightened opticfiber 1200. For example, when actuation structure 910 is fullycompressed, actuation nosecone 1000 may be fully extended relative tohandle 900.

Illustratively, a surgeon may aim optic fiber distal end 271 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 900 to orient shape memory sleeve260 in an orientation configured to cause a curvature of optic fiber 270within the particular transverse plane of the inner eye and varying anamount of compression of actuation structure 910. Illustratively, asurgeon may aim optic fiber distal end 271 at any target within aparticular sagittal plane of the inner eye by, e.g., rotating handle 900to orient shape memory sleeve 260 in an orientation configured to causea curvature of optic fiber 270 within the particular sagittal plane ofthe inner eye and varying an amount of compression of actuationstructure 910. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular frontal plane of theinner eye by, e.g., varying an amount of compression of actuationstructure 910 to orient a line tangent to optic fiber distal end 271wherein the line tangent to optic fiber distal end 271 is within theparticular frontal plane of the inner eye and rotating handle 900.Illustratively, a surgeon may aim optic fiber distal end 271 at anytarget located outside of the particular transverse plane, theparticular sagittal plane, and the particular frontal plane of the innereye, e.g., by varying a rotational orientation of handle 900 and varyingan amount of compression of actuation structure 910.

FIGS. 14A and 14B are schematic diagrams illustrating a handle 1400.FIG. 14A illustrates a top view of handle 1400. In one or moreembodiments, handle 1400 may comprise a handle distal end 1401, a handleproximal end 1402, a handle base 1405, an actuation structure 1410, anactuation ring 1415, a platform base 1420, an actuation mechanism guide1421, and a housing sleeve platform 1425. Illustratively, actuationstructure 1410 may comprise an actuation structure distal end 1411 andan actuation structure proximal end 1412. In one or more embodiments,actuation structure 1410 may comprise a plurality of actuation arms1413. Illustratively, each actuation arm 1413 may comprise at least oneextension mechanism 1414.

Illustratively, actuation structure 1410 may be compressed by anapplication of a compressive force to actuation structure 1410. In oneor more embodiments, actuation structure 1410 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 1410.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure1410. For example, a surgeon may compress actuation structure 1410 bysqueezing actuation structure 1410. Illustratively, the surgeon maycompress actuation structure 1410 by squeezing actuation structure 1410at any particular location of a plurality of locations around an outerperimeter of actuation structure 1410. For example, a surgeon may rotatehandle 1400 and compress actuation structure 1410 from any rotationalposition of a plurality of rotational positions of handle 1400.

In one or more embodiments, actuation structure 1410 may be compressedby an application of a compressive force to any one or more of theplurality of actuation arms 1413. Illustratively, each actuation arm1413 may be configured to actuate independently. In one or moreembodiments, each actuation arm 1413 may be connected to one or more ofthe plurality of actuation arms 1413 wherein an actuation of aparticular actuation arm 1413 may be configured to actuate everyactuation arm 1413 of the plurality of actuation arms 1413. In one ormore embodiments, a compression of actuation structure 1410, e.g., dueto an application of a compressive force to a particular actuation arm1413, may be configured to actuate the particular actuation arm 1413.Illustratively, an actuation of the particular actuation arm 1413 may beconfigured to actuate every actuation arm 1413 of the plurality ofactuation arms 1413. In one or more embodiments, an application of acompressive force to a particular actuation arm 1413 may be configuredto extend at least one extension mechanism 1414 of the particularactuation arm 1413.

Illustratively, a particular actuation arm 1413 may extend a firstlength from handle base 1405. An extension of an extension mechanism1414 of the particular actuation arm 1413, e.g., due to an applicationof a compressive force to the particular actuation arm 1413, may beconfigured to extend the particular actuation arm a second length fromhandle base 1405. Illustratively, the second length from handle base1405 may be greater than the first length from handle base 1405.

FIG. 14B illustrates a cross-sectional view of handle 1400. In one ormore embodiments, handle 1400 may comprise an inner bore 1430, an innerbore distal cone 1440, an inner bore proximal taper 1450, an optic fiberguide 1460, a shape memory sleeve guide 1465, an actuation mechanismhousing 1470, an actuation guide 1480, and a shape memory sleeve distalguide 1490. Handle 1400 may be manufactured from any suitable material,e.g., polymers, metals, metal alloys, etc., or from any combination ofsuitable materials.

FIG. 15 illustrates an exploded view of a steerable laser probe assembly1500. In one or more embodiments, steerable laser probe assembly 1500may comprise a handle 1400, an actuation mechanism 1510, a housingsleeve 250 having a housing sleeve distal end 251 and a housing sleeveproximal end 252, a shape memory sleeve 260 having a shape memory sleevedistal end 261 and a shape memory sleeve proximal end 262, an opticfiber 270 having an optic fiber distal end 271 and an optic fiberproximal end 272, and a light source interface 280. Illustratively,housing sleeve proximal end 252 may be fixed to housing sleeve platform1425 at handle distal end 1401.

In one or more embodiments, actuation ring 1415 may be fixed toactuation structure distal end 1411. Illustratively, a compression ofaction structure 1410 may be configured to extend actuation ring 1415,e.g., away from handle proximal end 1402 and towards handle distal end1401. In one or more embodiments, a decompression of actuation structure1410 may be configured to retract actuation ring 1415, e.g., away fromhandle distal end 1401 and towards handle proximal end 1402.Illustratively, actuation mechanism 1510 may be disposed withinactuation mechanism housing 1470. In one or more embodiments, acompression of actuation structure 1410 may be configured to actuateactuation mechanism 1510 within actuation mechanism guide 1421, e.g.,away from handle proximal end 1402 and towards handle distal end 1401.Illustratively, a decompression of actuation structure 1410 may beconfigured to actuate actuation mechanism 1510 within actuationmechanism guide 1421, e.g., away from handle distal end 1401 and towardshandle proximal end 1402.

Illustratively, optic fiber 270 may be disposed within shape memorysleeve 260, e.g., such that optic fiber distal end 271 is adjacent toshape memory sleeve distal end 261. Optic fiber 270 may be fixed in aposition within shape memory sleeve 260, e.g., with a biocompatibleadhesive or any suitable fixation means. In one or more embodiments,optic fiber 270 may be disposed within inner bore 1430 and optic fiberguide 1460. Illustratively, optic fiber 270 and shape memory sleeve 260may be disposed within shape memory sleeve guide 1465, actuation guide1480, shape memory sleeve distal guide 1490, and housing sleeve 250. Inone or more embodiments, optic fiber 270 and shape memory sleeve 260 maybe disposed in actuation mechanism housing 1470. Illustratively, opticfiber 270 and shape memory sleeve 260 may be attached to actuationmechanism 1510 wherein an actuation of actuation mechanism 1510 may beconfigured to actuate optic fiber 270 and shape memory sleeve 260. Forexample, an actuation of actuation mechanism 1510 within actuationmechanism guide 1421 may be configured to actuate optic fiber 270 andshape memory sleeve 260 relative to housing sleeve 250.

Illustratively, platform base 1420, housing sleeve platform 1425, andhousing sleeve 250 may be fixed in a position relative to handle base1405. In one or more embodiments, an actuation of actuation mechanism1510 within actuation mechanism guide 1421, i.e., away from handleproximal end 1402 and towards handle distal end 1401, may be configuredto extend optic fiber 270 and shape memory sleeve 260 out of housingsleeve 250. Illustratively, an actuation of actuation mechanism 1510within actuation mechanism guide 1421, i.e., away from handle distal end1401 and towards handle proximal end 1402, may be configured to retractoptic fiber 270 and shape memory sleeve 260 into housing sleeve 250.

In one or more embodiments, a compression of actuation structure 1410may be configured to actuate optic fiber 270 and shape memory sleeve 260relative to housing sleeve 250 wherein optic fiber 270 and shape memorysleeve 260 may be gradually extended from housing sleeve distal end 251.Illustratively, as optic fiber 270 and shape memory sleeve 260 aregradually extended from housing sleeve 250, e.g., due to a compressionof actuation structure 1410, shape memory sleeve 260 may gradually curveoptic fiber 270 towards pre-bent angle 265. In one or more embodiments,a decompression of actuation structure 1410 may be configured actuateoptic fiber 270 and shape memory sleeve 260 relative to housing sleeve250 wherein optic fiber 270 and shape memory sleeve 260 are graduallyretracted into housing sleeve distal end 251. Illustratively, as opticfiber 270 and shape memory sleeve 260 are gradually retracted intohousing sleeve 250, e.g., due to a decompression of actuation structure1410, shape memory sleeve 260 may gradually straighten optic fiber 270as housing sleeve 250 straightens pre-bent angle 265. In one or moreembodiments, an interior portion of housing sleeve 250 may be coatedwith a lubrication material configured to facilitate actuation of shapememory sleeve 260 and optic fiber 270 relative to housing sleeve 250.Illustratively, the lubrication material may comprise any suitablematerial, e.g., Teflon.

FIGS. 16A, 16B, and 16C illustrate a gradual curving of an optic fiber270. FIG. 16A illustrates a straightened optic fiber 1600.Illustratively, straightened optic fiber 1600 is fully contained withinhousing sleeve 250. In one or more embodiments, optic fiber 270 andshape memory sleeve 260 may be fully contained within housing sleeve250, e.g., when actuation structure 1410 is fully decompressed. Forexample, when actuation structure 1410 is fully decompressed, actuationmechanism 1510 may be fully retracted within actuation mechanism guide1421 and actuation ring 1415 may be fully retracted relative to housingsleeve platform 1425. Illustratively, when optic fiber 270 and shapememory sleeve 260 are fully contained within housing sleeve 250,pre-bent angle 265 of shape memory sleeve 260 may be straightened byhousing sleeve 250. For example, an angle between housing sleeve 250 anda line tangent to optic fiber distal end 271 may be, e.g., 180 degrees,when housing sleeve 250 contains a straightened optic fiber 1600.

FIG. 16B illustrates a partially curved optic fiber 1610. In one or moreembodiments, a compression of a fully decompressed actuation structure1410 may be configured to gradually extend optic fiber 270 and shapememory sleeve 260 from housing sleeve distal end 251. For example, asactuation structure 1410 is compressed, actuation ring 1415 andactuation mechanism 1510 may be gradually extended relative to handlebase 1405. Illustratively, as optic fiber 270 and shape memory sleeve260 are gradually extended from housing sleeve distal end 251, e.g., byan extension of actuation ring 1415 and actuation mechanism 1510relative to handle base 1405, shape memory sleeve 260 may cause opticfiber 270 to gradually curve towards pre-bent angle 265. In one or moreembodiments, a compression of actuation structure 1410 may be configuredto cause a straightened optic fiber 1600 to gradually curve to apartially curved optic fiber 1610. Illustratively, a compression ofactuation structure 1410 may gradually extend optic fiber 270 and shapememory sleeve 260 from housing sleeve distal end 251 as actuation ring1415 and actuation mechanism 1510 are extended relative to handle base1405. For example, as an extended length of optic fiber 270 and shapememory sleeve 260 is increased, e.g., by a compression of actuationstructure 1410, an angle between housing sleeve 250 and a line tangentto optic fiber distal end 271 may be decreased. Illustratively, opticfiber 270 and shape memory sleeve 260 may be extended from housingsleeve distal end 251 at a first length with a first angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271. Acompression of actuation structure 1410 may be configured to extendoptic fiber 270 and shape memory sleeve 260 from housing sleeve distalend 251 at a second length with a second angle between housing sleeve250 and a line tangent to optic fiber distal end 271. Illustratively,the second length may be greater than the first length and the secondangle may be less than the first angle.

FIG. 16C illustrates a fully curved optic fiber 1620. Illustratively, afull compression of actuation structure 1410 may be configured to extenda fully curved optic fiber 1620 from housing sleeve distal end 251. Forexample, as actuation structure 1410 is fully compressed, actuation ring1415 and actuation mechanism 1510 may be fully extended relative tohandle base 1405. In one or more embodiments, a compression of actuationstructure 1410 may be configured to cause a partially curved optic fiber1610 to gradually curve to a fully curved optic fiber 1620.Illustratively, optic fiber 270 and shape memory sleeve 260 may beextended from housing sleeve distal end 251 at a partially extendedlength with a partially extended angle between housing sleeve 250 and aline tangent to optic fiber distal end 271. A full compression ofactuation structure 1410 may be configured to extend optic fiber 270 andshape memory sleeve 260 from housing sleeve distal end 251 at fullyextended length with a fully extended angle between housing sleeve 250and a line tangent to optic fiber distal end 271. Illustratively, thefully extended length may be greater than the partially extended lengthand the fully extended angle may be less than the partially extendedangle.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing sleeve 250 extendsfrom handle distal end 1401 may be adjusted to vary an amount ofcompression of actuation structure 1410 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a position of actuationmechanism housing 1470 and actuation mechanism 1510 or a length of opticfiber 270 and shape memory sleeve 260 extending distally from a positionof actuation mechanism 1510 may be adjusted to vary an amount ofcompression of actuation structure 1410 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. For example, one or more dimensions ofplatform base 1420 may be adjusted to vary an amount of compression ofactuation structure 1410 configured to extend a particular length ofoptic fiber 270 and shape memory sleeve 260 from housing sleeve distalend 251. In one or more embodiments, a geometry of actuation structure1410 or a geometry of actuation ring 1415 may be adjusted to vary anamount of compression of actuation structure 1410 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a magnitude of pre-bentangle 265 may be adjusted to vary a magnitude of an angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271 whena particular length of optic fiber 270 and shape memory sleeve 260 isextended from housing sleeve distal end 251.

FIGS. 17A, 17B, and 17C illustrate a gradual straightening of an opticfiber 270. FIG. 17A illustrates an extended optic fiber 1700. In one ormore embodiments, a full compression of actuation structure 1410 may beconfigured to extend optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251 such that optic fiber 270 comprises anextended optic fiber 1700. Illustratively, shape memory sleeve 260 maybe configured to curve an extended optic fiber 1700 at pre-bent angle265. For example, when extended optic fiber 1700 extends from housingsleeve distal end 251, actuation ring 1415 and actuation mechanism 1510may be fully extended relative to handle base 1405.

FIG. 17B illustrates a partially refracted optic fiber 1710.Illustratively, a partially refracted optic fiber 1710 may be partiallycontained within housing sleeve 250 wherein housing sleeve 250 may beconfigured to straighten a portion of pre-bent angle 265. In one or moreembodiments, a decompression of actuation structure 1410 may beconfigured to retract optic fiber 270 and shape memory sleeve 260 intohousing sleeve 250 causing shape memory sleeve 260 to graduallystraighten optic fiber 270 from a fully curved optic fiber 1620 to apartially curved optic fiber 1610. For example, a decompression ofactuation structure 1410 may be configured to partially retractactuation ring 1415 and actuation mechanism 1510 relative to handledistal end 1401.

FIG. 17C illustrates a fully retracted optic fiber 1720. Illustratively,a fully retracted optic fiber 1720 may be fully contained within housingsleeve 250 wherein housing sleeve 250 may be configured to straightenpre-bent angle 265. In one or more embodiments, a full decompression ofactuation structure 1410 may be configured to retract optic fiber 270and shape memory sleeve 260 into housing sleeve 250 causing shape memorysleeve 260 to gradually straighten optic fiber 270 from a partiallycurved optic fiber 1610 to a straightened optic fiber 1600. For example,a full decompression of actuation structure 1410 may be configured tofully retract actuation ring 1415 and actuation mechanism 1510 relativeto handle distal end 1401.

Illustratively, a surgeon may aim optic fiber distal end 271 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 1400 to orient shape memory sleeve260 in an orientation configured to cause a curvature of optic fiber 270within the particular transverse plane of the inner eye and varying anamount of compression of actuation structure 1410. Illustratively, asurgeon may aim optic fiber distal end 271 at any target within aparticular sagittal plane of the inner eye by, e.g., rotating handle1400 to orient shape memory sleeve 260 in an orientation configured tocause a curvature of optic fiber 270 within the particular sagittalplane of the inner eye and varying an amount of compression of actuationstructure 1410. In one or more embodiments, a surgeon may aim opticfiber distal end 271 at any target within a particular frontal plane ofthe inner eye by, e.g., varying an amount of compression of actuationstructure 1410 to orient a line tangent to optic fiber distal end 271wherein the line tangent to optic fiber distal end 271 is within theparticular frontal plane of the inner eye and rotating handle 1400.Illustratively, a surgeon may aim optic fiber distal end 271 at anytarget located outside of the particular transverse plane, theparticular sagittal plane, and the particular frontal plane of the innereye, e.g., by varying a rotational orientation of handle 1400 andvarying an amount of compression of actuation structure 1410.

FIGS. 18A and 18B are schematic diagrams illustrating a handle 1800.FIG. 18A illustrates a top view of handle 1800. In one or moreembodiments, handle 1800 may comprise a handle distal end 1801, a handleproximal end 1802, a handle base 1805, an actuation structure 1810, anactuation platform 1820, and a housing sleeve platform 1825.Illustratively, actuation platform 1820 may comprise an actuationplatform distal end 1821 and an actuation platform proximal end 1822. Inone or more embodiments, actuation structure 1810 may comprise aplurality of actuation arms 1813. Illustratively, each actuation arm1813 may comprise at least one extension mechanism 1814. In one or moreembodiments, each actuation arm 1813 may comprise an inverted actuationjoint 1815.

Illustratively, actuation structure 1810 may be compressed by anapplication of a compressive force to actuation structure 1810. In oneor more embodiments, actuation structure 1810 may be compressed by anapplication of one or more compressive forces located at one or morelocations around an outer perimeter of actuation structure 1810.Illustratively, the one or more locations may comprise any of aplurality of locations around the outer perimeter of actuation structure1810. For example, a surgeon may compress actuation structure 1810 bysqueezing actuation structure 1810. Illustratively, the surgeon maycompress actuation structure 1810 by squeezing actuation structure 1810at any particular location of a plurality of locations around an outerperimeter of actuation structure 1810. For example, a surgeon may rotatehandle 1800 and compress actuation structure 1810 from any rotationalposition of a plurality of rotational positions of handle 1800.

In one or more embodiments, actuation structure 1810 may be compressedby an application of a compressive force to any one or more of theplurality of actuation arms 1813. Illustratively, each actuation arm1813 may be configured to actuate independently. In one or moreembodiments, each actuation arm 1813 may be connected to one or more ofthe plurality of actuation arms 1813 wherein an actuation of aparticular actuation arm 1813 may be configured to actuate everyactuation arm 1813 of the plurality of actuation arms 1813. In one ormore embodiments, a compression of actuation structure 1810, e.g., dueto an application of a compressive force to a particular actuation arm1813, may be configured to actuate the particular actuation arm 1813.Illustratively, an actuation of the particular actuation arm 1813 may beconfigured to actuate every actuation arm 1813 of the plurality ofactuation arms 1813. In one or more embodiments, an application of acompressive force to a particular actuation arm 1813 may be configuredto extend at least one extension mechanism 1814 of the particularactuation arm 1813.

Illustratively, an application of a compressive force to a particularactuation arm 1813 may be configured to retract actuation platform 1820relative to handle base 1805. In one or more embodiments, as aparticular actuation arm 1813 is compressed, e.g., due to an applicationof a compressive force to the particular actuation arm 1813, an invertedactuation joint 1815 of the particular actuation arm 1813 may beconfigured to gradually retract actuation platform 1820 relative tohandle base 1805. For example, when a compressive force is applied to aparticular actuation arm 1813, e.g., and the particular actuation arm1813 is extended by at least one extension mechanism 1815 of theparticular actuation arm 1813, an inverted actuation joint 1815 of theparticular actuation arm 1813 may be configured to retract actuationplatform 1820 relative to handle base 1805.

FIG. 18B illustrates a cross-sectional view of handle 1800. In one ormore embodiments, handle 1800 may comprise an inner bore 1830, an innerbore proximal taper 1850, an actuation mechanism housing 1870, an innerbore distal chamber 1880, and a shape memory sleeve guide 1890. Handle1800 may be manufactured from any suitable material, e.g., polymers,metals, metal alloys, etc., or from any combination of suitablematerials.

FIG. 19 illustrates an exploded view of a steerable laser probe assembly1900. In one or more embodiments, steerable laser probe assembly 1900may comprise a handle 1800, an actuation mechanism 1910, a housingsleeve 250 having a housing sleeve distal end 251 and a housing sleeveproximal end 252, a shape memory sleeve 260 having a shape memory sleevedistal end 261 and a shape memory sleeve proximal end 262, an opticfiber 270 having an optic fiber distal end 271 and an optic fiberproximal end 272, and a light source interface 280. Illustratively,housing sleeve proximal end 252 may be fixed to housing sleeve platform1825 at handle distal end 1801.

Illustratively, a compression of action structure 1810 may be configuredto retract actuation platform 1820, e.g., towards handle proximal end1802 and away from handle distal end 1801. In one or more embodiments, adecompression of actuation structure 1810 may be configured to extendactuation platform 1820, e.g., towards handle distal end 1801 and awayfrom handle proximal end 1802. Illustratively, actuation mechanism 1910may be disposed within actuation mechanism housing 1870. In one or moreembodiments, a compression of actuation structure 1810 may be configuredto actuate actuation mechanism 1910 and actuation platform 1820, e.g.,towards handle proximal end 1802 and away from handle distal end 1801.Illustratively, a decompression of actuation structure 1810 may beconfigured to actuate actuation mechanism 1910 and actuation platform1820, e.g., towards handle distal end 1801 and away from handle proximalend 1802.

Illustratively, optic fiber 270 may be disposed within shape memorysleeve 260, e.g., such that optic fiber distal end 271 is adjacent toshape memory sleeve distal end 261. Optic fiber 270 may be fixed in aposition within shape memory sleeve 260, e.g., with a biocompatibleadhesive or any suitable fixation means. In one or more embodiments,optic fiber 270 may be disposed within inner bore 1830 and inner boredistal chamber 1880. Illustratively, optic fiber 270 and shape memorysleeve 260 may be disposed within shape memory sleeve guide 1890 andhousing sleeve 250. In one or more embodiments, optic fiber 270 andshape memory sleeve 260 may be disposed in actuation mechanism housing1870. Illustratively, optic fiber 270 and shape memory sleeve 260 may beattached to actuation mechanism 1910 wherein an actuation of actuationmechanism 1910 may be configured to actuate optic fiber 270 and shapememory sleeve 260. For example, an actuation of actuation mechanism 1910and actuation platform 1820 may be configured to actuate optic fiber 270and shape memory sleeve 260 relative to housing sleeve 250.

Illustratively, housing sleeve platform 1825 and housing sleeve 250 maybe fixed in a position relative to handle base 1805. In one or moreembodiments, an actuation of actuation mechanism 1910 and actuationplatform 1820, i.e., away from handle proximal end 1802 and towardshandle distal end 1801, may be configured to extend optic fiber 270 andshape memory sleeve 260 out of housing sleeve 250. Illustratively, anactuation of actuation mechanism 1910 and actuation platform 1820, i.e.,away from handle distal end 1801 and towards handle proximal end 1802,may be configured to retract optic fiber 270 and shape memory sleeve 260into housing sleeve 250.

In one or more embodiments, a decompression of actuation structure 1810may be configured to actuate optic fiber 270 and shape memory sleeve 260relative to housing sleeve 250 wherein optic fiber 270 and shape memorysleeve 260 may be gradually extended from housing sleeve distal end 251.Illustratively, as optic fiber 270 and shape memory sleeve 260 aregradually extended from housing sleeve 250, e.g., due to a decompressionof actuation structure 1810, shape memory sleeve 260 may gradually curveoptic fiber 270 towards pre-bent angle 265. In one or more embodiments,a compression of actuation structure 1810 may be configured actuateoptic fiber 270 and shape memory sleeve 260 relative to housing sleeve250 wherein optic fiber 270 and shape memory sleeve 260 are graduallyretracted into housing sleeve distal end 251. Illustratively, as opticfiber 270 and shape memory sleeve 260 are gradually refracted intohousing sleeve 250, e.g., due to a compression of actuation structure1810, shape memory sleeve 260 may gradually straighten optic fiber 270as housing sleeve 250 straightens pre-bent angle 265. In one or moreembodiments, an interior portion of housing sleeve 250 may be coatedwith a lubrication material configured to facilitate actuation of shapememory sleeve 260 and optic fiber 270 relative to housing sleeve 250.Illustratively, the lubrication material may comprise any suitablematerial, e.g., Teflon.

FIGS. 20A, 20B, and 20C illustrate a gradual curving of an optic fiber270. FIG. 20A illustrates a straightened optic fiber 2000.Illustratively, straightened optic fiber 2000 is fully contained withinhousing sleeve 250. In one or more embodiments, optic fiber 270 andshape memory sleeve 260 may be fully contained within housing sleeve250, e.g., when actuation structure 1810 is fully compressed. Forexample, when actuation structure 1810 is fully compressed, actuationmechanism 1910 and actuation platform 182 may be fully retractedrelative to housing sleeve platform 1825. Illustratively, when opticfiber 270 and shape memory sleeve 260 are fully contained within housingsleeve 250, pre-bent angle 265 of shape memory sleeve 260 may bestraightened by housing sleeve 250. For example, an angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271 maybe, e.g., 180 degrees, when housing sleeve 250 contains a straightenedoptic fiber 2000.

FIG. 20B illustrates a partially curved optic fiber 2010. In one or moreembodiments, a decompression of a fully compressed actuation structure1810 may be configured to gradually extend optic fiber 270 and shapememory sleeve 260 from housing sleeve distal end 251. For example, asactuation structure 1810 is decompressed, actuation mechanism 1910 andactuation platform 1820 may be gradually extended relative to handlebase 1805. Illustratively, as optic fiber 270 and shape memory sleeve260 are gradually extended from housing sleeve distal end 251, e.g., byan extension of actuation mechanism 1910 and actuation platform 1820relative to handle base 1805, shape memory sleeve 260 may cause opticfiber 270 to gradually curve towards pre-bent angle 265. In one or moreembodiments, a decompression of actuation structure 1810 may beconfigured to cause a straightened optic fiber 2000 to gradually curveto a partially curved optic fiber 2010. Illustratively, a decompressionof actuation structure 1810 may gradually extend optic fiber 270 andshape memory sleeve 260 from housing sleeve distal end 251 as actuationmechanism 1910 and actuation platform 1820 are extended relative tohandle base 1805. For example, as an extended length of optic fiber 270and shape memory sleeve 260 is increased, e.g., by a decompression ofactuation structure 1810, an angle between housing sleeve 250 and a linetangent to optic fiber distal end 271 may be decreased. Illustratively,optic fiber 270 and shape memory sleeve 260 may be extended from housingsleeve distal end 251 at a first length with a first angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271. Adecompression of actuation structure 1810 may be configured to extendoptic fiber 270 and shape memory sleeve 260 from housing sleeve distalend 251 at a second length with a second angle between housing sleeve250 and a line tangent to optic fiber distal end 271. Illustratively,the second length may be greater than the first length and the secondangle may be less than the first angle.

FIG. 20C illustrates a fully curved optic fiber 2020. Illustratively, afull decompression of actuation structure 1810 may be configured toextend a fully curved optic fiber 2020 from housing sleeve distal end251. For example, as actuation structure 1810 is fully decompressed,actuation mechanism 1910 and actuation platform 1820 may be fullyextended relative to handle base 1805. In one or more embodiments, adecompression of actuation structure 1810 may be configured to cause apartially curved optic fiber 2010 to gradually curve to a fully curvedoptic fiber 2020. Illustratively, optic fiber 270 and shape memorysleeve 260 may be extended from housing sleeve distal end 251 at apartially extended length with a partially extended angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271. Afull decompression of actuation structure 1810 may be configured toextend optic fiber 270 and shape memory sleeve 260 from housing sleevedistal end 251 at fully extended length with a fully extended anglebetween housing sleeve 250 and a line tangent to optic fiber distal end271. Illustratively, the fully extended length may be greater than thepartially extended length and the fully extended angle may be less thanthe partially extended angle.

In one or more embodiments, one or more properties of a steerable laserprobe may be adjusted to attain one or more desired steerable laserprobe features. For example, a length that housing sleeve 250 extendsfrom handle distal end 1801 may be adjusted to vary an amount ofdecompression of actuation structure 1810 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a position of actuationmechanism housing 1870 and actuation mechanism 1910 or a length of opticfiber 270 and shape memory sleeve 260 extending distally from a positionof actuation mechanism 1910 may be adjusted to vary an amount ofdecompression of actuation structure 1810 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. For example, one or more dimensions ofactuation platform 1820 may be adjusted to vary an amount ofdecompression of actuation structure 1810 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. In one or more embodiments, a geometry ofactuation structure 1810 may be adjusted to vary an amount ofdecompression of actuation structure 1810 configured to extend aparticular length of optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251. Illustratively, a magnitude of pre-bentangle 265 may be adjusted to vary a magnitude of an angle betweenhousing sleeve 250 and a line tangent to optic fiber distal end 271 whena particular length of optic fiber 270 and shape memory sleeve 260 isextended from housing sleeve distal end 251.

FIGS. 21A, 21B, and 21C illustrate a gradual straightening of an opticfiber 270. FIG. 21A illustrates an extended optic fiber 2100. In one ormore embodiments, a full decompression of actuation structure 1810 maybe configured to extend optic fiber 270 and shape memory sleeve 260 fromhousing sleeve distal end 251 such that optic fiber 270 comprises anextended optic fiber 2100. Illustratively, shape memory sleeve 260 maybe configured to curve an extended optic fiber 2100 at pre-bent angle265. For example, when extended optic fiber 2100 extends from housingsleeve distal end 251, actuation mechanism 1910 and actuation platform1820 may be fully extended relative to handle base 1805.

FIG. 21B illustrates a partially retracted optic fiber 2110.Illustratively, a partially refracted optic fiber 2110 may be partiallycontained within housing sleeve 250 wherein housing sleeve 250 may beconfigured to straighten a portion of pre-bent angle 265. In one or moreembodiments, a compression of actuation structure 1810 may be configuredto retract optic fiber 270 and shape memory sleeve 260 into housingsleeve 250 causing shape memory sleeve 260 to gradually straighten opticfiber 270 from a fully curved optic fiber 2020 to a partially curvedoptic fiber 2010. For example, a compression of actuation structure 1810may be configured to partially retract actuation mechanism 1910 andactuation platform 1820 relative to handle distal end 1801.

FIG. 21C illustrates a fully retracted optic fiber 2120. Illustratively,a fully retracted optic fiber 2120 may be fully contained within housingsleeve 250 wherein housing sleeve 250 may be configured to straightenpre-bent angle 265. In one or more embodiments, a full compression ofactuation structure 1810 may be configured to retract optic fiber 270and shape memory sleeve 260 into housing sleeve 250 causing shape memorysleeve 260 to gradually straighten optic fiber 270 from a partiallycurved optic fiber 2010 to a straightened optic fiber 2000. For example,a full compression of actuation structure 1810 may be configured tofully retract actuation mechanism 1910 and actuation platform 1820relative to handle distal end 1801.

Illustratively, a surgeon may aim optic fiber distal end 271 at any of aplurality of targets within an eye, e.g., to perform a photocoagulationprocedure. In one or more embodiments, a surgeon may aim optic fiberdistal end 271 at any target within a particular transverse plane of theinner eye by, e.g., rotating handle 1800 to orient shape memory sleeve260 in an orientation configured to cause a curvature of optic fiber 270within the particular transverse plane of the inner eye and varying anamount of compression of actuation structure 1810. Illustratively, asurgeon may aim optic fiber distal end 271 at any target within aparticular sagittal plane of the inner eye by, e.g., rotating handle1800 to orient shape memory sleeve 260 in an orientation configured tocause a curvature of optic fiber 270 within the particular sagittalplane of the inner eye and varying an amount of compression of actuationstructure 1810. In one or more embodiments, a surgeon may aim opticfiber distal end 271 at any target within a particular frontal plane ofthe inner eye by, e.g., varying an amount of compression of actuationstructure 1810 to orient a line tangent to optic fiber distal end 271wherein the line tangent to optic fiber distal end 271 is within theparticular frontal plane of the inner eye and rotating handle 1800.Illustratively, a surgeon may aim optic fiber distal end 271 at anytarget located outside of the particular transverse plane, theparticular sagittal plane, and the particular frontal plane of the innereye, e.g., by varying a rotational orientation of handle 1800 andvarying an amount of compression of actuation structure 1810.

The foregoing description has been directed to particular embodiments ofthis invention. It will be apparent; however, that other variations andmodifications may be made to the described embodiments, with theattainment of some or all of their advantages. Specifically, it shouldbe noted that the principles of the present invention may be implementedin any probe system. Furthermore, while this description has beenwritten in terms of a surgical instrument handle for selectivelyactuating a shape memory sleeve and an optic fiber relative to a housingsleeve and for selectively actuating a housing sleeve relative to ashape memory sleeve and an optic fiber, the teachings of the presentinvention are equally suitable to systems where the functionality ofactuation may be employed. Therefore, it is the object of the appendedclaims to cover all such variations and modifications as come within thetrue spirit and scope of the invention.

1. An instrument comprising: a handle having a handle distal end and ahandle proximal end; a housing sleeve having a housing sleeve distal endand a housing sleeve proximal end; a shape memory sleeve having a shapememory sleeve distal end and a shape memory sleeve proximal end, theshape memory sleeve at least partially disposed within the housingsleeve; a pre-bent angle of the shape memory sleeve; an optic fiberhaving an optic fiber distal end and an optic fiber proximal end, theoptic fiber disposed within an optic fiber guide of the handle and theshape memory sleeve; an actuation structure of the handle having anactuation structure distal end and an actuation structure proximal end;and a plurality of actuation arms of the actuation structure, eachactuation arm of the plurality of actuation arms having at least oneextension mechanism.
 2. The instrument of claim 1 wherein a compressionof the actuation structure is configured to gradually curve the opticfiber.
 3. The instrument of claim 2 wherein the compression of theactuation structure is configured to gradually retract the housingsleeve relative to the shape memory sleeve and the optic fiber.
 4. Theinstrument of claim 2 wherein the compression of the actuation structureis configured to gradually extend the shape memory sleeve and the opticfiber relative to the housing sleeve.
 5. The instrument of claim 1wherein a decompression of the actuation structure is configured togradually curve the optic fiber.
 6. The instrument of claim 5 whereinthe decompression of the actuation structure is configured to graduallyretract the housing sleeve relative to the shape memory sleeve and theoptic fiber.
 7. The instrument of claim 1 wherein a compression of theactuation structure is configured to gradually straighten the opticfiber.
 8. The instrument of claim 7 wherein the compression of theactuation structure is configured to gradually extend the housing sleeverelative to the shape memory sleeve and the optic fiber.
 9. Theinstrument of claim 1 wherein a decompression of the actuation structureis configured to gradually straighten the optic fiber.
 10. Theinstrument of claim 9 wherein the decompression of the actuationstructure is configured to gradually extend the housing sleeve relativeto the shape memory sleeve and the optic fiber.
 11. The instrument ofclaim 9 wherein the decompression of the actuation structure isconfigured to gradually retract the shape memory sleeve and the opticfiber relative to the housing sleeve.
 12. The instrument of claim 1further comprising: a fixation lip fixed to the actuation structuredistal end; and a nosecone fixed to the fixation lip wherein the housingsleeve proximal end is fixed to a portion of the nosecone.
 13. Theinstrument of claim 1 further comprising: a pressure mechanism disposedwithin a pressure mechanism housing of the handle, the pressuremechanism configured to provide a force; and an actuation cone having anactuation cone distal end and an actuation cone proximal end, theactuation cone proximal end disposed within the actuation structure. 14.The instrument of claim 1 further comprising: an actuation noseconehaving an actuation nosecone distal end and an actuation noseconeproximal end; an actuation structure interface of the actuationnosecone, the actuation structure interface configured to interface withthe handle distal end; and a shape memory sleeve guide of the actuationnosecone.
 15. The instrument of claim 14 further comprising: a pistontube housing of the actuation nosecone; and a piston tube having apiston tube having a piston tube distal end and a piston tube proximalend, the piston tube distal end disposed within the piston tube housing.16. The instrument of claim 1 further comprising: an actuation ringfixed to the actuation structure distal end; a platform base of thehandle; and a housing sleeve platform fixed to the platform base, thehousing sleeve proximal end fixed to a portion of the housing sleeveplatform.
 17. The instrument of claim 17 further comprising: anactuation mechanism housing of the actuation ring; an actuationmechanism guide of the platform base; and an actuation mechanismdisposed in the actuation mechanism housing and the actuation mechanismguide.
 18. A method comprising: inserting a distal end of an optic fiberinto an eye; identifying a first photocoagulation target tissue withinthe eye; cauterizing the first photocoagulation target tissue within theeye; identifying a second photocoagulation target tissue within the eye;adjusting an amount of a force applied to at least one actuation arm ofan actuation structure of an instrument handle; curving the optic fiber;and cauterizing the second photocoagulation target tissue within theeye.
 19. The method of claim 18 further comprising: increasing theamount of the force applied to the at least one actuation arm of theactuation structure of the instrument handle.
 20. The method of claim 18further comprising: decreasing the amount of the force applied to the atleast one actuation arm of the actuation structure of the instrumenthandle.